It is written in most CBD products label/descriptions “not to be taken with other medications”, and if at all it would be, it should be under the supervision of a physician. These warnings/advice is similar to the ban on grapefruits taken with medication. Is there a similarity in the reasons why both grapefruit and CBD should not interact with drugs or just coincidence?

What are the CBD compounds?
CBD compounds comes from the hemp extract of the cannabis plant and contain a negligible amount of THC in them at worst. THC (tetrahydrocannabinol) compounds are the intoxicating substance in cannabis plants, which makes them less desirable; they originate from marijuana-based cannabis. Although CBD compounds are widely reported to have great therapeutic benefits to the human body, its combined use with existing medications especially when not prescribed by a doctor is considered a NAY.

Herbs/plants vs. medications, and effects
Physicians and medical practitioners warn that just like grapefruit, CBD compounds are known to contain compounds like (cytochrome 450) that suppresses the enzyme that plays a major role in drug metabolism. Even when people argue that it is a herb, and should have no interaction with drugs; the example of grapefruit will prove that not all herbs and chemicals should be ‘mixed’ indiscriminately in the body. From research on the effects of CBD on medications: CBD interacts with meds in mixed ways, for some meds, it magnifies the effect, for others, it suppresses the effect of the meds. Here, let us compare the different interaction these medications have when taken with CBD compounds;

CBD vs. Medications with a risk of bleeding
Research has shown that when you take CBD or other cannabinoids together with drugs that might cause the blood to thin or possess a risk of the blood-thinning, they are capable of making the effects of such drugs linger for a long time in the body. Prolonged effects of drugs like warfarin, ibuprofen in the body (due to intake with CBD) could lead to complications in the circulatory system.

CBD vs. Sedatives
Here is another example of CBD interactions amplifying the effects of drugs; when CBD compounds interact with sedatives in the body, they can prolong the effects of these sedatives. CBD in the body system reacts with neurotransmitters and receptors in the body; this action forms the foundation of their therapeutic powers.

CBD vs chemotherapy drugs
Although CBD has been reported to reduce the destructive pace of cancer and serve as a relief to pains, it should always be on strict prescription if it is to be taken with drugs used in chemotherapy. Chemotherapy drugs are narrow index therapeutic drugs (there exists a thin line between its healing powers and its toxicity), and should be taken in the strictest and precise way possible. You should not risk interactions between your chemotherapy meds and CBD compounds as it could unnecessarily tilt the (drug conc balance).

Do they or do they not…
Amongst the numerous cannabinoids; there are very few studies on their interactions with medications in the human body. While CBD is not known to have any side effects on its own, the same cannot be said for when it interacts with other drugs. And just like the Grapefruit example, it proves that not all herbs/plants and drugs can be mixed indiscriminately.